Immunopathogenesis of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever with special emphasis on immunopathogenesis.

Dengue virus infections are a serious cause of morbidity and mortality in most tropical and subtropical areas of the world; Southeast and South Asia, Central and South America, and the Caribbean. Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal. Pathogenesis...

Dengue and dengue hemorrhagic fever.

Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. More than 200,000,000 infections and over 2 million cases of DHF occur annually, and dengue is one of the most important emerging tropical diseases in the world. Its dramatically increased incidence and geogr...

Dengue and Dengue Hemorrhagic Fever

Dengue and dengue hemorrhagic fever.

Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tro...

Dengue Hemorrhagic Fever and Dengue Shock Syndrome

The Dengue virus is an arbovirus, from genus Flavivirus family Flaviviridae. It is a single stranded RNA genome surrounded by an icosahedral nucleocapsid and covered by lipid envelope. Four serotypes: DEN-1, 2, 3, 4 have been identified for the virus. Each serotype provides specific lifetime immunity, but only a shortterm cross-immunity. All serotypes can cause severe and fatal disease. In the ...